Biography
Dr. John Stone is Director of Clinical Rheumatology at Massachusetts General Hospital, and Associate Professor of Medicine, Division of Rheumatology at Harvard Medical School. Dr. Stone co-founded the Vasculitis Center at Johns Hopkins University and directed a multi-center, randomized clinical trial in Wegener's granulomatosis. The results of this trial were published in The New England Journal of Medicine (2005). Dr. Stone is currently the Co-PI of a second multi-center clinical trial in ANCA-associated vasculitis: Rituximab in ANCA-Associated Vasculitis HRAVe. The primary results of this trial were recently published in The New England Journal of Medicine (2010).
Dr. Stone’s most current research interest pertains to an emerging disease known as IgG4-related systemic disease (IgG4-RSD). Dr. Stone’s research group at the MGH made the seminal observation that rituximab therapy leads to the targeted reduction of the IgG4 subclass of immunoglobulins in this disorder.